Gambogic Acid Inhibits Hsp90 Expressions in Thiram-Induced Tibial Dyschondroplasia
نویسندگان
چکیده
Received: Revised: Accepted: Published online: March 26, 2015 July 23, 2015 August 25, 2015 December 31, 2015 Tibial Dyschondroplasia (TD) is an important leg problem in fast growing birds that disturbs the proximal tibial growth plate. A study was conducted to evaluate the effects of gambogic acid (GA) on hsp-90 expressions and antioxidant capability in thiram-induced TD chicken. One hundred and fifty day-old commercial broiler chicks were distributed into three groups: Control (A), thiram-induced (B) and GA treated (C). Tibial bone samples were collected at day 7 & 14 to evaluate hsp-90 expressions and liver samples were procured at the end of experiment to determine the antioxidant enzymes. As compared to control, the results demonstrated that significant increased hsp-90 gene expressions (P<0.05) in thiram-induced TD chicks on day 7 & 14 contributing to the progression of TD while a decrease in antioxidant capacity of liver on day 14. On administering the GA, the hsp-90 expressions were down-regulated and restored the antioxidant capacity of liver significantly (P<0.05). In conclusion, the GA ameliorated the growth plate vascularization in TD-afflicted chicks which provides a new clinical usage of this promising agent against TD. ©2015 PVJ. All rights reserved
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